| Overall | Total | Starts | Used Substitute | Unused Substitute | Scorers |
| Neves R | 177 | Marcel | 31 | Kashloul H | 4 |
| Moutinho J | 175 | Kightly M | 31 | Jonsson E | 3 |
| Traore A | 157 | Camara H | 30 | Chiwome L | 3 |
| Coady C | 151 | Cameron C | 30 | Bent M | 3 |
| Jimenez R | 135 | Newton S | 28 | Hill M | 2 |
| Semedo N | 131 | Trincoa | 28 | Vallejo | 2 |
| Kilman M | 127 | Johnson R | 27 | Murray M | 1 |
| Dendoncker L | 124 | Collins N | 26 | Andrews K | 1 |
| Patricio R | 112 | Doyle T | 26 | Friend G | 1 |
| Neto P | 111 | Miller K | 25 | Buur O | 1 |
| Saiss R | 110 | Costa H | 25 | Jordoa B | 1 |
| Sa J | 108 | Costa D | 23 | Ikeme C | 1 |
| Jarvis M | 108 | Cavaleiro I | 23 | Corbeau T | 1 |
| Jonny | 107 | Bellegarde J | 22 | Ronan C | 1 |
| Doherty M | 105 | Oakes M | 21 | Gonzalez E | 1 |
| Ait-Nouri R | 98 | Hoever K | 20 | Cooper K | 1 |
| Berra C | 96 | Hammill A | 19 | Lembikisa D | 1 |
| Henry K | 94 | Vitinha | 19 | Norris W | 1 |
| Ward S | 94 | Halford G | 17 | Gorman J | 1 |
| Doyle K | 93 | Jose W | 17 | Sarkic M | 0 |
| Podence D | 91 | Jones PS | 16 | Mosquera Y | 0 |
| Boly W | 89 | Cort C | 16 | Hause K | 0 |
| Hwang H | 86 | Iversen S | 16 | Richards L | 0 |
| Craddock J | 81 | Ganea I | 16 | Moulden | 0 |
| Stearman R | 77 | Iwelumo C | 15 | Ashley-Seal B | 0 |
| Ebanks-Blake S | 76 | Keogh A | 14 | Barnett T | 0 |
| Foley K | 74 | Cutrone P | 14 | Giles R | 0 |
| Hennessey W | 71 | Blake N | 13 | Marques C | 0 |
| Jota D | 67 | Guedes G | 13 | Marshall A | 0 |
| Milijas N | 62 | Bueno S | 12 | Perry T | 0 |
| Silva F | 62 | Kalajdzic S | 12 | Lemina N | 0 |
| Edwards D | 61 | Gudjonsson J | 11 | Okoduwa T | 0 |
| Fletcher S | 61 | Vokes S | 11 | King T | 0 |
| Elokobi G | 58 | Bassong S | 9 | Batth D | 0 |
| Toti | 56 | Clyde M | 9 | Griffiths H | 0 |
| Lemina M | 54 | Silas G | 9 | Holman F | 0 |
| Zubar R | 53 | Maierhofer S | 9 | Lonwijk N | 0 |
| Cunha M | 49 | Castillo S | 8 | Shabani M | 0 |
| Gibbs-White M | 48 | Chirewa T | 8 | Sonderland A | 0 |
| Mancienne M | 46 | Chiquinho | 8 | Campana L | 0 |
| Bennett R | 45 | Okoronkwo I | 7 | Winnall S | 0 |
| Gomes J | 45 | Davis D | 7 | Clingan S | 0 |
| Hunt S | 44 | Bentley D | 7 | Ebanks-Landell E | 0 |
| Sarabia P | 43 | Surman A | 7 | Enobakhare B | 0 |
| Bueno H | 43 | Fraser N | 7 | Griffiths L | 0 |
| Dawson C | 42 | Bonatini L | 7 | Hesketh O | 0 |
| Hahnemann M | 39 | Luzhny O | 6 | Hubner J | 0 |
| Naylor L | 38 | van Damme J | 6 | Ingimarsson I | 0 |
| Butler P | 37 | Forde A | 6 | John C | 0 |
| Nunes M | 36 | Otasowie O | 6 | Lowe K | 0 |
| Vinagre R | 35 | Hodge J | 6 | Ojinnaka T | 0 |
| Guedioura A | 34 | Campbell C | 6 | Price J | 0 |
| Traore B | 34 | Frimpong E | 5 | Rooney N | 0 |
| O’Hara J | 33 | Ruddy JTG (John) | 5 | Sanderson D | 0 |
| Rae A | 33 | Sturridge D | 5 | Spray J | 0 |
| Ince P | 32 | de Vries D | 4 | Storer J | 0 |
| Irwin D | 32 | Cundle L | 4 | Whittingham M | 0 |
| Jones DF (David) | 32 | Mouyokolo S | 4 | ||
| Kennedy M | 31 | Mujangi Bia G | 4 |
