Friday 25 March 1921 at Millfields Road (Att 10,000)

Clapton Orient (0) 0: Hugall, Bradbury, Osmond, Dixon, Townrow, Nicholson, Smith, Gillatt, Cockle, Parker, Williams.
Wolves (0) 1 (Sambrook 75): George, Newell, Baugh, Thomas, Caddick, Woodward, Lea, Cutler, Sambrook, Potts, Richards.

Referee: Mr E Pullan (Leeds).
Landmark: Percy Newell makes his Football League debut.
Position: 14th.