Saturday 20 August 1949 at Craven Cottage (Att 43,854)

Fulham (0) 1 (Bacuzzi 75): Flack, Freeman, Bacuzzi, Quested, Taylor, Beesley, Stevens, Thomas, Rowley, Jezzard, McDonald.
Wolves (1) 2 (Mullen 29, Hancocks 59): Williams, Kelly, Pritchard, Crook, Shorthouse, Wright, Hancocks, Smyth, Pye, Dunn, Mullen.

Referee: Mr E Vickery (Bristol).
Order of Goals: W,W,f.
Landmark: Jesse Pye makes his 100th League appearance.
Celebration: Fulham take their bow in the First Division with their first ever game in the topflight.
Position: 5th.