Saturday 28 October 1922 at The Dell (Att 13,000)

Southampton (3) 3 (Getgood 10, Dominy 31, Rawlings 42): Allen, Parker, Titmuss, Shelley, Getgood, Turner, Brown, Dominy, Rawlings, Elkes, Clarke.
Wolves (0) 0: Hampton, Baugh, Marshall, Gregory, Hodnett, Kay, Best, McMillan, Edmonds, Bisset, McCall.

Referee: Mr J Sharpe (Lichfield).
Landmark: Bobby Best makes his 100th League appearance.
Position: 21st.