Sunday 26 September 2021 at St Mary’s Stadium (Att 28,002)

Southampton (0) 0: McCarthy, Livramento, Bednarek, Salisu, Walker-Peters (Long 74), Romeu, Ward-Prowse, Elyounoussi, Redmond (Djenepo 64), Armstrong, Adams (Broja 64); Subs Forster, Perraud, Valery, Lyanco, Diallo, Tella.
Wolves (0) 1 (Jimenez 61): Sa, Semedo (Hoever 87), Marcal, Kilman, Coady, Saiss, Dendoncker, Moutinho, Podence (Traore 69), Hwang (Neves 87), Jimenez; Subs Ruddy, Moulden, Boly, Cundle, Trincao, Silva.

Referee: Mr A Madley.
Television: Match shown live on Sky.
Position: 14th.