| A | G | |||||||
| 103 | 16 August 1980 | Goldstone Ground | Brighton & Hove Albion | L | 0-2 | Division 1 | 1 | |
| 104 | 19 August 1980 | Molineux | Manchester Utd | W | 1-0 | Division 1 | 1 | 1 |
| 105 | 23 August 1980 | Hawthorns | West Bromwich Albion | D | 1-1 | Division 1 | 1 | |
| 106 | 26 August 1980 | Abbey Stadium | Cambridge United | L | 1-3 | League Cup 2/1 | 1 | |
| 107 | 30 August 1980 | Molineux | Crystal Palace | W | 2-0 | Division 1 | 1 | |
| 108 | 2 September 1980 | Molineux | Cambridge United | L | 0-1 | League Cup 2/2 | 1 | |
| 109 | 6 September 1980 | Goodison Park | Everton | L | 0-2 | Division 1 | 1 | |
| 110 | 13 September 1980 | Molineux | Coventry City | L | 0-1 | Division 1 | 1 | |
| 111 | 17 September 1980 | Phillips Stadium | PSV Eindhoven | L | 1-3 | UEFA Cup 1/1 | 1 | |
| 112 | 20 September 1980 | Villa Park | Aston Villa | L | 1-2 | Division 1 | 1 | |
| 01 October 1980 | Molineux | PSV Eindhoven | W | 1-0 | UEFA Cup 1/2 | Un Used | ||
| 11 October 1980 | Carrow Road | Norwich City | D | 1-1 | Division 1 | Un Used | ||
| 113 | 25 October 1980 | Filbert Street | Leicester City | L | 0-2 | Division 1 | 1 | |
| 114 | 27 December 1980 | Maine Road | Manchester City | L | 0-4 | Division 1 | 1 | |
| 115 | 3 January 1981 | Victoria Ground | Stoke City | D | 2-2 | FAC 3 | 1 | |
| 116 | 6 January 1981 | Molineux | Stoke City | W | 2-1 | FAC 3R | 1 | |
| 117 | 10 January 1981 | Molineux | Middlesbrough | W | 3-0 | Division 1 | 1 | |
| 118 | 17 January 1981 | Selhurst Park | Crystal Palace | D | 0-0 | Division 1 | 1 | |
| 119 | 24 January 1981 | Vicarage Road | Watford | D | 1-1 | FAC 4 | 1 | |
| 120 | 27 January 1981 | Molineux | Watford | W | 2-1 | FAC 4R | 1 | |
| 121 | 31 January 1981 | Molineux | West Bromwich Albion | W | 2-0 | Division 1 | 1 | |
| 122 | 7 February 1981 | Highfield Road | Coventry City | D | 2-2 | Division 1 | 1 | |
| 123 | 14 February 1981 | Molineux | Wrexham | W | 3-1 | FAC 5 | 1 | |
| 124 | 21 February 1981 | Portman Road | Ipswich Town | L | 1-3 | Division 1 | 1 | |
| 125 | 28 February 1981 | Molineux | Aston Villa | L | 0-1 | Division 1 | 1 | |
| 126 | 7 March 1981 | Ayresome Park | Middlesbrough | D | 1-1 | FAC 6 | 1 | |
| 127 | 10 March 1981 | Molineux | Middlesbrough | W | 3-1 | FAC 6R | 1 | |
| 128 | 14 March 1981 | Molineux | Norwich City | W | 3-0 | Division 1 | 1 | |
| 129 | 17 March 1981 | St Andrews | Birmingham City | L | 0-1 | Division 1 | 1 | |
| 130 | 21 March 1981 | Elland Road | Leeds United | W | 3-1 | Division 1 | 1 | |
| 131 | 28 March 1981 | Molineux | Leicester City | L | 0-1 | Division 1 | 1 | |
| 132 | 4 April 1981 | Roker Park | Sunderland | W | 1-0 | Division 1 | 1 | |
| 133 | 11 April 1981 | Hillsborough | Tottenham Hotspur | D | 2-2 | FAC SF | 1 | |
| 134 | 15 April 1981 | Highbury | Tottenham Hotspur | L | 0-3 | FAC SFR | 1 | |
| 135 | 18 April 1981 | Molineux | Manchester City | L | 1-3 | Division 1 | 1 | |
| 136 | 20 April 1981 | City Ground | Nottingham Forest | L | 0-1 | Division 1 | 1 | |
| 137 | 25 April 1981 | Molineux | Arsenal | L | 1-2 | Division 1 | 1 | 1og |
| 138 | 30 April 1981 | Molineux | Tottenham Hotspur | W | 1-0 | Division 1 | 1 | |
| 139 | 2 May 1981 | Victoria Ground | Stoke City | L | 2-3 | Division 1 | 1 |
