| 17 September 1980 | Phillips Stadium | PSV Eindhoven | L | 1-3 | UEFA Cup 1/1 | Un-Used | ||
| 8 | 20 September 1980 | Villa Park | Aston Villa | L | 1-2 | Division 1 | 1 | |
| 9 | 27 September 1980 | Molineux | Ipswich Town | L | 0-2 | Division 1 | 1 | |
| 10 | 1 October 1980 | Molineux | PSV Eindhoven | W | 1-0 | UEFA Cup 1/2 | 0+1 | |
| 11 | 1 November 1980 | Molineux | Sunderland | W | 2-1 | Division 1 | 1 | |
| 12 | 8 November 1980 | White Hart Lane | Tottenham Hotspur | D | 2-2 | Division 1 | 1 | 1 |
| 13 | 12 November 1980 | Old Trafford | Manchester Utd | D | 0-0 | Division 1 | 1 | |
| 14 | 15 November 1980 | Molineux | Brighton & Hove Albion | L | 0-2 | Division 1 | 1 | |
| 15 | 22 November 1980 | Ayresome Park | Middlesbrough | L | 0-2 | Division 1 | 1 | |
| 16 | 25 November 1980 | Molineux | Liverpool | W | 4-1 | Division 1 | 1 | |
| 17 | 6 December 1980 | Highbury | Arsenal | D | 1-1 | Division 1 | 1 | |
| 18 | 13 December 1980 | Molineux | Southampton | D | 1-1 | Division 1 | 1 | |
| 19 | 20 December 1980 | Anfield | Liverpool | L | 0-1 | Division 1 | 1 | |
| 20 | 26 December 1980 | Molineux | Nottingham Forest | L | 1-4 | Division 1 | 1 | |
| 21 | 27 December 1980 | Maine Road | Manchester City | L | 0-4 | Division 1 | 0+1 | |
| 22 | 3 January 1981 | Victoria Ground | Stoke City | D | 2-2 | FAC 3 | 1 | |
| 23 | 6 January 1981 | Molineux | Stoke City | W | 2-1 | FAC 3R | 1 | |
| 24 | 10 January 1981 | Molineux | Middlesbrough | W | 3-0 | Division 1 | 1 | |
| 25 | 17 January 1981 | Selhurst Park | Crystal Palace | D | 0-0 | Division 1 | 1 | |
| 26 | 24 January 1981 | Vicarage Road | Watford | D | 1-1 | FAC 4 | 1 | |
| 27 | 31 January 1981 | Molineux | West Bromwich Albion | W | 2-0 | Division 1 | 1 | |
| 28 | 7 February 1981 | Highfield Road | Coventry City | D | 2-2 | Division 1 | 1 | |
| 29 | 14 February 1981 | Molineux | Wrexham | W | 3-1 | FAC 5 | 1 | |
| 30 | 21 February 1981 | Portman Road | Ipswich Town | L | 1-3 | Division 1 | 1 | |
| 31 | 4 April 1981 | Roker Park | Sunderland | W | 1-0 | Division 1 | 1 | |
| 32 | 18 April 1981 | Molineux | Manchester City | L | 1-3 | Division 1 | 1 | |
| 33 | 30 April 1981 | Molineux | Tottenham Hotspur | W | 1-0 | Division 1 | 0+1 | |
| 34 | 2 May 1981 | Victoria Ground | Stoke City | L | 2-3 | Division 1 | 0+1 |
