| First Team | Second Team Matches | League debuts | Associated with both clubs | Transfers |
| Order | Date | Player | Venue | Results | Extra Info | Season | |
| 255 | 19 November 1921 | Hargreaves, H | Molineux | L | 0-1 | 1921/22 | |
| 549 | 7 September 1966 | Burnside, D | Molineux | D | 1-1 | 1g | 1966/67 |
| 586 | 10 March 1972 | Powell, B | Selhurst Park | D | 1-1 | Sub | 1972/73 |
| 618 | 30 August 1980 | Villazan, R | Molineux | W | 2-1 | 1980/81 | |
| 633 | 27 November 1982 | Dodd, A | Selhurst Park | W | 4-3 | 1982/83 | |
| 665 | 9 March 1985 | Biggins, S | Selhurst Park | D | 0-0 | 1984/85 | |
| 749 | 15 January 1994 | Ferguson, D | Molineux | W | 2-0 | 1993/94 | |
| 750 | 15 January 1994 | Marsden, C | Molineux | W | 2-0 | 1993/94 | |
| 809 | 28 September 1999 | Taylor, S | Selhurst Park | L | 0-1 | 1999/00 | |
| 888 | 28 November 2006 | McIndoe, M | Molineux | D | 1-1 | Sub | 2006/07 |
| 905 | 12 January 2008 | Ebanks, S | Selhurst Park | L | 0-3 | 2007/08 | |
| 913 | 16 September 2008 | Shackell, J | Molineux | W | 2-1 | Sub | 2008/09 |
| 1079 | 11 May 2024 | Gonzalez, E | Molineux | L | 1-3 | Sub | 2023/24 |
