| First Team Matches | Second Team Matches | Youth Team Matches | League debuts | Associated with both clubs | Transfers |
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| Season | Competition | Date | Venue | Results | ||
| 1887/88 | Friendly | 19 May 1888 | North Road | L | 1-2 | As Newton Heath |
| 1888/89 | Friendly | 26 December 1888 | Dudley Road | W | 6-1 | |
| 1892/93 | Football League | 15 October 1892 | North Road | L | 1-10 | |
| 1892/93 | Football League | 17 December 1892 | Molineux | W | 2-0 | |
| 1893/94 | Football League | 28 October 1893 | Molineux | W | 2-0 | |
| 1893/94 | Football League | 11 November 1893 | Bank Street | L | 0-1 | |
| 1922/23 | Football League | 9 September 1922 | Molineux | L | 0-1 | As Manchester United |
| 1922/23 | Football League | 16 September 1922 | Old Trafford | L | 0-1 | |
| 1924/25 | Football League | 28 February 1924 | Old Trafford | L | 0-3 | |
| 1924/25 | Football League | 25 October 1924 | Molineux | D | 0-0 | |
| 1931/32 | Football League | 25 December 1931 | Old Trafford | L | 2-3 | |
| 1931/32 | Football League | 26 December 1931 | Molineux | W | 7-0 | |
| 1936/37 | Football League | 29 August 1936 | Old Trafford | D | 1-1 | |
| 1936/37 | Football League | 26 December 1936 | Molineux | W | 3-1 | |
| 1938/39 | Football League | 12 November 1938 | Old Trafford | W | 3-1 | |
| 1938/39 | Football League | 18 March 1939 | Molineux | W | 3-0 | |
| 1941/42 | War Time | 11 April 1942 | Maine Road | L | 4-5 | |
| 1941/42 | War Time | 18 April 1942 | Molineux | W | 2-0 | |
| 1946/47 | Football League | 30 November 1946 | Molineux | W | 3-2 | |
| 1946/47 | Football League | 5 April 1947 | Maine Road | L | 1-3 | |
| 1947/48 | Football League | 20 March 1948 | Maine Road | L | 2-3 | |
| 1948/49 | Football League | 8 September 1948 | Molineux | W | 3-2 | |
| 1948/49 | Football League | 15 September 1948 | Maine Road | L | 0-2 | |
| 1947/48 | Football League | 1 November 1948 | Molineux | L | 2-6 | |
| 1948/49 | FA Cup | 26 March 1949 | Hillsborough | D | 1-1 | |
| 1948/49 | FA Cup | 2 April 1949 | Goodison Park | W | 1-0 | |
| 1949/50 | Football League | 22 October 1949 | Old Trafford | L | 0-3 | |
| 1949/50 | Football League | 8 April 1950 | Molineux | D | 1-1 | |
| 1950/51 | Football League | 30 September 1950 | Molineux | D | 0-0 | |
| 1950/51 | Football League | 17 February 1951 | Old Trafford | L | 1-2 | |
| 1951/52 | Football League | 27 October 1951 | Molineux | L | 0-2 | |
| 1951/52 | Football League | 15 March 1952 | Old Trafford | L | 0-2 | |
| 1952/53 | Football League | 4 October 1952 | Molineux | W | 6-2 | |
| 1952/53 | Football League | 21 February 1953 | Old Trafford | W | 3-0 | |
| 1953/54 | Football League | 17 October 1953 | Molineux | W | 3-1 | |
| 1953/54 | Football League | 6 March 1954 | Old Trafford | L | 0-1 | |
| 1954/55 | Football League | 2 October 1954 | Molineux | W | 4-2 | |
| 1954/55 | Football League | 23 February 1955 | Old Trafford | W | 4-2 | |
| 1955/56 | Football League | 8 October 1955 | Old Trafford | L | 3-4 | |
| 1955/56 | Football League | 18 February 1956 | Molineux | L | 0-2 | |
| 1956/57 | Football League | 3 November 1956 | Old Trafford | L | 0-3 | |
| 1956/57 | Football League | 16 March 1957 | Molineux | D | 1-1 | |
| 1957/58 | Football League | 28 September 1957 | Molineux | W | 3-1 | |
| 1957/58 | Football League | 21 April 1958 | Old Trafford | W | 4-0 | |
| 1958/59 | Football League | 4 October 1958 | Molineux | W | 4-0 | |
| 1958/59 | Football League | 21 February 1959 | Old Trafford | L | 1-2 | |
| 1959/60 | Football League | 17 October 1959 | Molineux | W | 3-2 | |
| 1959/60 | Football League | 5 March 1960 | Old Trafford | W | 2-0 | |
| 1960/61 | Football League | 24 September 1960 | Old Trafford | W | 3-1 | |
| 1960/61 | Football League | 11 February 1961 | Molineux | W | 2-1 |
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